LOVE AND SCIENCE: A MEMOIR

Book ID/图书代码： 12070015B81885

English Summary/英文概要：

Chinese Summary/中文概要： 世界上现存最伟大科学家的回忆录，有关于其所遭受的迫害，流放和生物医学发现。

在成为世界上最著名的微生物学家之前，因为父母均为犹太人，并且整个欧洲都在对犹太人进行种族灭绝政策，让·维尔塞克的童年是在斯洛伐克度过的。二战结束后，作为一名在捷克斯洛伐克长大的青年维尔塞克上了医学院并选择了童年时期就喜欢的领域：微生物学。20岁时，塞尔维克便主持召开了第一届国际干扰素会议，并在著名的期刊杂志《自然》上发表了一篇论文。与妻子玛丽卡一同逃离了共产主义社会的捷克斯洛伐克后，维尔塞克继续在纽约大学医学院中进行他的研究，保护着38项微生物学领域专利，并创造出了我们时代最流行和最领先，最前沿的药物。

在《热爱与科学：回忆录》中，维尔塞克用巨大的热情为我们娓娓道来他的故事----有关于他所面临的巨大阻碍是如何以一种极其不真实的方式与他充满乐趣的科学发现人生携手并进，或者最重要的是，有关于爱与友情不仅仅是通向快乐的关键，更是引领他通向成功的关键。

1965年塞尔维克初到美国，身无分文也没有工作，他很快便继续在人体成纤维细胞干扰素和相关蛋白质的生产上引领发展并取得了关键性的进展，并且通过其对于肿瘤坏死因子（TNF）的研究逐渐取得进展，也使得他因此发现了新的基因、蛋白质以及信号途径，从而打开了医学创新的新天地，也因此直接引发了对于一些常见疾病的全新疗法的出现。

《热爱与科学》为我们展现了科学领域的进步常常源自于此前的巨大失落，以及医学研究领域的成就通常都是一支团队共同努力的结果，在这样的一支团队中，成员们相互分享观点，在这支团队中，友情至关重要，爱的力量甚至足以与聪明才智的重要性相匹敌，而运气则和知识一样缺一不可，只不过有时随着时间的推移，最意料之外的事情却往往成为了最至关重要的那件事。在维尔塞克的故事中，曾经无数人声称在干扰素中看到了癌症的治愈之光，并曾占据了报刊杂志的封面篇幅，却最终未能付诸实现。然而即便如此，在那一堆希望的灰烬之中，却衍生出了许多对于相关疾病的治疗方案，并因此改变了无数人的人生，减轻了病人们的大量痛苦。(DC)

Awards/获奖情况：“让·维尔塞克的这部回忆录讲述了一个有关于两段密切相关旅程的动人故事---一个充满了科学性，另一个则是十分私密。这段个人旅程的跨度也是十分惊人：在布拉迪斯拉法度过的，在纳粹法西斯主义破坏下支离破碎的童年，生活在共产主义的影子下，以及逃亡到新大陆。他的科学之旅亦是同样跨度广阔---从最初的探索免疫学和微生物学，到发现整个时代中最最惊人的药品。在这两段旅程中，我们均遇到了探险之旅的过程中最不可或缺的元素：探索的紧迫感，灵感的稍纵即逝，错误的诱导，突如其来的成功，机缘巧合的重要性，失败与奋斗过程中磨人的起起伏伏---然而最终要的是，那种强有力的不甘心最终促使了我们去探索和发现崭新的世界。本书实在是令我读来爱不释手。”--- Siddhartha Mukherjee

"Readers curious about the intimate and mysterious mechanism within our bodies and expansive world without will be awarded by Dr. Jan Vilcek’s memoir. It’s an exploration of the public history of the 20th century on a personal level, a personal journey to overcome many obstacles to ease the pains of millions, and a conversation in depth with the readers about arts and sciences. An unusual memoirist, Dr. Vilcek does not make himself the center of a heroic narrative but gives space to colleagues, friends and family, yet emerging from this narrative is the unmistakably wise, warm, optimistic and modest soul of a great man." —Yiyun Li

"A memoir of the extraordinary life and circumstances that led the author to the groundbreaking discovery of Remicade, which successfully treats two previously untreatable autoimmune diseases, Crohn’s disease and rheumatoid arthritis.In 2013, Vilcek (editor: American Odysseys: Writings by New Americans, 2012, etc.) was awarded the National Medal of Technology and Innovation by President Barack Obama for his discovery, which utilized a protein naturally produced in the human body’s defense system against tumors. In that year, Remicade was reported to be "the second-highest selling drug in the world, with sales of $10.1 billion." Born in 1933 to a middle-class Jewish family in what is now Slovakia, Vilcek and his family were among the relatively few Jews to escape the Holocaust while remaining in Czechoslovakia. In his estimate, this was due to the family’s decision to convert to Catholicism and his father’s position as a business executive. In 1948, Czechoslovakia was taken over by communists, and the author and his family were forced to adjust to the new totalitarian regime. After attending medical school, Vilcek married and pursued a research career in the upcoming field of virology. He established contacts with Western researchers who facilitated the publication of his work. Despite the fact that he had launched a productive career, he and his wife wanted to escape the oppressive political regime. With help from Western friends, Vilcek was invited to join the faculty at New York University’s School of Medicine, where he ran his own laboratory. His continued effort to find a treatment for autoimmune diseases proved successful and resulted in the commercial development of Remicade, which received FDA approval in 2000. His share of royalties has allowed him and his wife to sponsor careers in science and the arts. Vilcek artfully joins the chronicle of his scientific work and the dramatic events that punctuated his life under two totalitarian regimes, culminating in his flight to freedom. An inspiring page-turner. "

LOVE AND SCIENCE was featured among Nature top picks for 2016 in arts & sciences!
http://www.nature.com/news/books-arts-of-2016-1.21185

About the Author/作者介绍： 让·T·维尔塞克是纽约大学Langone 医学中心的一名微生物学教授。他出生于布拉迪斯拉法，捷克（后名捷克斯洛伐克），同时拥有医学博士学位和博士学位，1965年时，维尔塞克与他身为艺术史学家的妻子玛丽卡·维尔塞克一同移民至美国，并前往纽约大学医学院就职。维尔塞克是最早从事干扰素研究的科学家之一，干扰素是一种对于免疫系统十分重要的蛋白质成分。维尔塞克博士在理解控制人体免疫系统的蛋白质上所作出的贡献对促进抗生素药物Remicade®的发展有着重大的指引作用，Remicade®是全新的TNF治疗系列中的首位“成员”，该系列药品现已被广泛用于治疗克罗恩病、溃疡性结肠炎、内风湿性关节炎、牛皮癣以及许多其他慢性炎症性疾病。维尔塞克博士迄今已出版了超过350篇学术论文，并为多部专业书籍进行写作或编辑工作，此外，他还被称为是38项美国国家专利技术的联合发明人。凭借其发现和慈善事业，维尔塞克获得了2013年度国家技术奖和奥巴马总统颁发的创新奖。

Format:

Rights Status/版权销售情况：Simplified Chinese/简体中文：AVAILABLE

Complex/Traditional Chinese/繁体中文：AVAILABLE

Sales in other countries/其他国家销售情况：Rights to LOVE AND SCIENCE have been sold in Slovakia. Also, a review of the book will appear in Nature’s next issue!

原文第一章内容：暂无

手稿：暂无

大纲：暂无