GENENTECH: THE BEGINNINGS OF BIOTECH

Book ID/图书代码： 13560015B82360

English Summary/英文概要： In the fall of 1980, Genentech, Inc., a little-known California genetic engineering company, became the overnight darling of Wall Street, raising over $38 million in its initial public stock offering. Lacking marketed products or substantial profit, the firm nonetheless saw its share price escalate from $35 to $89 in the first few minutes of trading, at that point the largest gain in stock market history. Coming at a time of economic recession and declining technological competitiveness in the United States, the event provoked banner headlines and ignited a period of speculative frenzy over biotechnology as a revolutionary means for creating new and better kinds of pharmaceuticals, untold profit, and a possible solution to national economic malaise.

Drawing from an unparalleled collection of interviews with early biotech players, Sally Smith Hughes offers the first book-length history of this pioneering company, depicting Genentech’s improbable creation, precarious youth, and ascent to immense prosperity. Hughes provides intimate portraits of the people significant to Genentech’s science and business, including cofounders Herbert Boyer and Robert Swanson, and in doing so sheds new light on how personality affects the growth of science. By placing Genentech’s founders, followers, opponents, victims, and beneficiaries in context, Hughes also demonstrates how science interacts with commercial and legal interests and university research, and with government regulation, venture capital, and commercial profits.

Integrating the scientific, the corporate, the contextual, and the personal, Genentech tells the story of biotechnology as it is not often told, as a risky and improbable entrepreneurial venture that had to overcome a number of powerful forces working against it.

Chinese Summary/中文概要： 生物技术产业开山鼻祖与领跑者——基因泰克官方**授权传记

精彩再现基因泰克从默默无闻到走上巅峰的跌宕起伏的神奇历程

Genentech，中文译作基因泰克，是全球**的生物科技公司。该书忠实介绍了基因泰克跌宕起伏的精彩创业史，似乎能让读者回到那个让人激动的年代。

基因泰克是由罗伯特·斯万森与生物化学家赫伯特·伯耶共同创立，其中伯耶是重组DNA领域的专家，而年轻有为的斯万森当时则是一位失业的落魄风险投资家。斯万森敏锐的商业头脑与眼光，加上伯耶精深的专业技能，迸发出巨大的能量。基因泰克公司的成立被认为是生物科技研究的起点。之后，众多生物技术公司紧随其后，纷纷成立。基因泰克首创的产学结合、与大的制药企业合作的模式，至今仍未很多生物技术公司效仿。

1980年秋，这家成立不足4年的公司在纳斯达克上市，尽管当时营收很少，利润微薄，但华尔街非常看好它的发展。其股票在上市后的**个小时，股价就从35美元上涨到88美元。这一事件点燃了生物技术发展的狂潮。(DB)

Awards/获奖情况：“Hughes has crafted an engaging historical account of Genentech from its beginnings as a small laboratory at the University of California, San Francisco to the 2009 merger with Roche for 47 billion dollars. . . . [Her] account will appeal to a broad audience and is a must read for scholars interested in the history of biotechnology. Highly recommended.” (J. A. Hewlett Choice)

“[A]n important addition to the history of biotech.” (Phillip A. Sharp, Massachusetts Institute of Technology Nature Medicine)

“Over the past 20 years Sally Smith Hughes has done a great service to science studies by conducting in-depth oral-history interviews with prominent scientists, venture capitalists, corporate leaders, and attorneys in the history and business of early biotechnology. She drew on her unprecedented access to corporate records and a large number of actors and their oral histories to write Genentech, the first comprehensive account of the creation and early development of the Genentech Corporation.” (Doogab Yi Chemical Heritage Magazine)

“The author skillfully reveals the practical, day-to-day, hands-on roles played by venture capitalists focused on fiscal gain and scientists focused on scientific breakthroughs. . . . [A] fascinating read.” (Valerie McGurk Nursing Standard)

“[A]n eminently readable (and, for classes, eminently assignable) story . . . . Smith Hughes is one of the foremost oral historians of science today, and Genentech is filled with illuminating interview snippets woven artfully into a narrative that both engages and (somewhat surreptitiously) analyzes. . . . [F]or a case study that lays out in lively detail the ambiguities and exuberances of high-tech entrepreneurship, Smith Hughes’s Genentech surely ranks among the very best.” (Cyrus C. M. Mody, Rice University Bulletin of the History of Medicine)

“[A] fascinating book, vividly recount[ing] the blood, sweat, and tears of the early days of ‘genetic engineers’ working at the bench, designing new biomolecules, and capitalizing their promises on Wall Street.” (Social History of Medicine)

“Genentech: The Beginnings of Biotech paints a wonderfully detailed picture of an important beginning in the history of biotechnology.” (Nathan Crowe, Arizona State University Journal of the History of Biology)
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About the Author/作者介绍： 萨莉·史密斯·休斯供职于加州伯克利大学班克罗夫特图书馆，是科学历史方面的专家，著有《病毒的历史》（The Virus: A History of the Concept）。此外，她还创作了一系列广泛深入的口述历史，内容涉及生物科学、生物医药学和生物技术领域。

Sally Smith Hughes is a historian of science at the Bancroft Library at the University of California, Berkeley. She is the author of The Virus: A History of the Concept and the creator of an extensive collection of in-depth oral histories on bioscience, biomedicine, and biotechnology.

Format:HARDCOVER

Rights Status/版权销售情况：Simplified Chinese/简体中文：SOLD

Complex/Traditional Chinese/繁体中文：AVAILABLE

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