P53: THE GENE THAT CRACKED THE CANCER CODE

Book ID/图书代码： 02000014B68794

English Summary/英文概要： All of us have lurking in our DNA a most remarkable gene. Its job is straightforward - to protect us from cancer. This gene - known simply as p53 - constantly scans our cells to ensure that they grow and divide without mishap, as part of the routine maintenance of our bodies. If a cell makes a mistake in copying its DNA as part of its process of division, p53 stops it in its tracks, sending in the repair team before allowing the cell to carry on dividing. If the mistake is irreparable and the rogue cell threatens to grow out of control (as happens in cancer), p53 commands the cell to commit suicide. Cancer cannot develop unless p53 itself is damaged and malfunctioning. Not surprisingly, p53 is the most studied gene in history. This enormously important gene has teased the minds of some of the most colourful and ambitious scientists around the world. These characters populate Sue Armstrong’s book p53: The Gene that Cracked the Cancer Code, the story of medical science’s mission to unravel the mysteries of this gene and to get to the heart of what happens in our cells when they turn cancerous. p53: The Gene that Cracked the Cancer Code reveals the tale of the search for this gene, as well as the excitement of the hunt for new cures - the hype, the lost opportunities, the blind alleys and the thrilling breakthroughs. As the long-anticipated revolution in cancer treatment tailored to each individual patient’s symptoms starts to take off at last, p53 is still at the forefront of the game. This is a timely tale of scientific discovery and advances in our understanding of a disease that still affects more than one in three of us at some point in our lives.

Chinese Summary/中文概要： 在我们每个人的DNA里，都潜伏着一种最为卓越的基因。它的工作便是勇往直前----保卫我们不受癌症的侵蚀。这种基因有着一个极为简单的名字：p53---它不停的扫描我们的细胞，确保我们的细胞健康的成长与分化，而没有遇到任何的不幸事件，它是我们身体日常维护的一部分。如果一个细胞在分裂的进程中对DNA进行复制时发生了一个小小的失误，P53就会组织它的行为，将它送往待修阵营，只有完成了修复才能重新回来继续进行分裂活动。如果这个小失误是无法修复的，而这个淘气的小细胞有种愈来愈壮大、即将取得控制权的态势（通常会以癌症的形式呈现），P53就会要求这一细胞进行自杀。除非P53自身遭到损坏且无法正常工作，否则癌症是无法发展起来的。毋庸置疑的是，P53确实是历史上研究的最多的一种基因。这一极端重要的基因还曾和世界上最传奇也最有野心的科学家们开过玩笑。这些人物都将出现在苏??阿姆斯特朗的这部著作《P53：破解癌症密码的基因》中，讲述了医药科学的任务：揭开这种基因的神秘面纱，弄清当我们得癌症时，我们身体中的基因所发生的变化及其根本原因。《P53：破解癌症密码的基因》不仅揭开了寻找这一基因的故事，同时还揭开了寻找新的治愈之法所带来的激动之情---那些骗局、那些失去的机会、那些死胡同、以及那些令人震惊的突破。长久以来，人们一直期待的契合于每一个人症状的癌症治疗中的新革命终将开始，P53还将处于革命的先锋位置。对于癌症这样一种在生命的某些时刻，影响着我们当中1/3人群的疾病而言，本书对科学发现与进步的及时描绘，使得我们对之有了另种的理解。（DC）

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About the Author/作者介绍： 苏??阿姆斯特朗是一名科学作家和广播员，居住在爱丁堡。作者曾效力于各类媒体机构，其中包括《新科学》，并且从20世纪80年代后，苏便开始承担来自世界卫生组织和联合国艾滋病联合规划署的一些常规性事务，写作关于女性健康话题以及艾滋病的盛行的一些文章，她也会创作其他话题的文章，报道来自于前线国家，如海地、巴布亚新几内亚、乌干达、泰国纳米比亚和叙利亚等国的消息。苏曾作为演讲人、作家和研究者参与过数次较为重大的BBC4台的纪录片的拍摄录制。

Sue Armstrong is a science writer and broadcaster based in Edinburgh. She has worked for a variety of media organisations, including New Scientist, and since the 1980s has undertaken regular assignments for the World Health Organization (WHO) and UNAIDS, writing about women’s health issues and the AIDS pandemic, among many other topics, and reporting from the frontline in countries as diverse as Haiti, Papua New Guinea, Uganda, Thailand, Namibia and Serbia. Sue has been involved, as presenter, writer and researcher, in several major medical documentaries for BBC Radio 4.

Format:HARDCOVER

Rights Status/版权销售情况：Simplified Chinese/简体中文：AVAILABLE(到期可授)

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